Hartman Behavioral Neuroscience Lab



  1. 1. Milner E, Holtzman J, Friess S, Hartman R, Brody D, Han B & Zipfel G (2014) Endovascular-perforation subarachnoid hemorrhage fails to cause Morris water maze deficits in the mouse. Journal of Cerebral Blood Flow and Metabolism, in press.

  2. 2. Karain B, Xu D, Bellone J, Hartman RE, Shi W (2014) Globus pallidal neurons: Functional classification and effects of dopamine depletion. Synapse, in press.

  3. 3. Dulcich MS & Hartman RE (2013) Pomegranate supplementation improves affective and motor behavior in mice after radiation exposure, Evidence-based Complementary and Alternative Medicine.

  1. 4. Ropacki SA, Patel SM, & Hartman RE (2013) Pomegranate supplementation protects from memory dysfunction after heart surgery, a pilot study, Evidence-based Complementary and Alternative Medicine.

  1. 5. Ashwal S, Ghosh N, Turenius C, Dulcich M, Denham C, Tone B, Hartman R, Snyder E & Obenaus A (2013) The reparative effects of neural stem cells in neonatal hypoxic ischemic injury are not influenced by host gender. Pediatric Research, 75(5), 603-611.

  1. 6. Manaenko A,  Lekic T, Barnhart M, Hartman RE & Zhang J (2013) Inhibition of TGF-β attenuates brain injury and neurological deficits in a rat model of GMH, Stroke, 45(3), 45-55.

  1. 7. Kamper JE, Pop V, Fukuda AM, Ajao DO, Hartman R, Badaut J (2013). Juvenile traumatic brain injury evolves into a chronic brain disorder: behavioral and histological changes over 6 months. Experimental Neurology, 250, 8-19.

  1. 8. Fukuda AM, Adami A, Pop V, Bellone JA, Coats JS, Hartman RE, Ashwal S, Obenaus A, & Badaut  J (2013) Posttraumatic reduction of edema with aquaporin-4 RNA interference improves acute and chronic functional recovery, Journal of Cerebral Blood Flow and Metabolism, in press.

  1. 9. Rolland WB, Lekic T, Krafft PR, Hasagawa Y, Altaya O, Hartman R, Ostrowski R, Manaenko A, Tang J, & Zhang J (2013) Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage. Exper Neurol. 241,  45-55.

  1. 10. Huang L, Coats JS, Mohd-Yusof A, Yin Y, Assad S, Muellner MJ, Kamper JE, Hartman RE, Dulcich M, Donovan VM, Oyoyo U, Obenaus A (2013) Tissue vulnerability is increased following repetitive mild traumatic brain injury in the rat. Brain Res. 1499,  109-120.

  1. 11. Lekic T, Rolland W, Manaenko A, Krafft P, Kamper J, Suzuki H, Hartman RE, Tang J, & Zhang J (2013). Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage. Journal of Neurosurgery, 118(2), 465-477.

  1. 12. Pop V, Sorensen D, Kamper J, Ajao D, Murphy P, Head E, Hartman R, Badaut J (2013). Early brain injury alters the blood-brain barrier phenotype in parallel with beta-amyloid and cognitive changes in adulthood. Journal of Cerebral Blood Flow and Metabolism 33, 205-214.

  1. 13. Hartman RE (2012). Assessment of cognitive and sensorimotor deficits Chen J, Xu XM, Xu ZC, Zhang JH, editors, Animal models of acute neurological injuries II: Injury and mechanistic assessments. Springer. 235-253.

  1. 14. Zhang J, Badaut J, Tang J, Obenaus A, Hartman R, & Pearce W (2012) The vascular neural network: The central unit of stroke pathophysiology. Nature Neurol Rev 8, 711-716.

  1. 15. Donovan V, Bianchi A, Hartman R, Bhanu B, Carson MJ, Obenaus A (2012) Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury. Neuroimage:Clinical 1(1), 18-28.

  1. 16. Ajao D, Pop V, Kamper J, Hartman RE, Badaut J (2012) Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered tissue properties in adulthood. Journal of Neurotrauma, 29(11), 2060-74.

  1. 17. Obenaus A, Huang L, Coats JS, Hartman R, Badaut B, & Ashwal S (2012) Animal models, Kirkwood MW & Owen Yeates K, editors. Mild Traumatic Brain Injury in Children and Adolescents: From Basic Science to Clinical Management. Guilford Press.

  1. 18. Lekic T, Manaenko A, Rolland W, Krafft PR, Peters R, Hartman RE, Altay O, Tang J, & Zhang JH (2012) Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus. Experimental Neurology, 236(1), 69-78.

  1. 19. Hartman RE, Kamper JE, Goyal R, Stewart J, & Longo L (2011) Motor and cognitive deficits in mice bred to have low or high blood pressure. Physiology and Behavior, 105, 1092-1097.

  1. 20. Hartman RE (2011) A brief history of experimental assessment following experimental traumatic brain injury in juveniles. Translational Stroke Research, 2, 433-437.

  1. 21. Bertolizio G, Bissonnette B, Mason L, Ashwal S, Hartman R, Marcantonio S, Obenaus A. (2011) Effects of hemodilution after traumatic brain injury in juvenile rats. Paediatr Anaesth 21(12):1198-208.

  1. 22. Lekic T, Manaenko A, Rolland W, Virbel K, Hartman R, Tang J, Zhang JH. (2011) Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats. Acta Neurochir Suppl, 111, 201-206.

  1. 23. Chen W, Ma Q, Suzuki H, Hartman R, Tang J, and Zhang J. (2011). Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke, 42(3), 764-769.

  1. 24. Lekic T, Rolland W, Hartman R, Kamper J, Suzuki H, Tang J. (2011). Characterization of the brain injury, neurobehavioral profiles and histopathology in a rat model of cerebellar hemorrhage. Exper Neurol 227, 96-103.

  2. commentary by Gary Rosenberg

  1. 25. Obenaus A, Dilmac N, Tone B, Tian HR, Hartman RE, Digicaylioglu M, Snyder EY, and Ashwal, S (2010). Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury. Ann Neurol, 69(2), 282-291.

  1. 26. Lekic T, Hartman R, Rojas H, Manaenko A, Chen W, Ayer R, Tang J, and Zhang JH. (2010). Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. J Neurotrauma 27(3) 627-37.

  1. 27. Hartman, RE (2009). Actions of bioactive phytochemicals in cell function and Alzheimer's disease pathology. L. Packer, H. Sies, M. Eggersdorfer & E. Cadenas, editors. Micronutrients and Brain Health. Oxygen Club of California.

  1. 28. Chen W, Hartman R, Ayer R, Marcantonio S, Kamper J, Tang J, and Zhang JH. (2009). Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. J Neurochem 111(3) 726-36.

  1. 29. Hartman R, Lekic T, Rojas H, Tang J, and Zhang JH. (2009). Assessing functional outcomes following intracerebral hemorrhage in rats Brain Res 1280 148-57.

  1. 30. Recker R, Adami A, Tone B, Tian HR, Lalas S, Hartman RE, Obenaus A, and Ashwal S. (2009). Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic-ischemic injury. J Cereb Blood Flow Metab 29(7) 1305-16.

  1. 31. Hartman, R.E. (2008). Brain injury as a risk factor for Alzheimer’s disease: Therapeutic implications. J.H. Zhang, editor. Advancements in Neurological Research (Ch 6). Research Signpost, 141-177.

  1. 32. Hartman RE, Rojas HA, Lekic T, Ayer R, Lee S, Jadhav V, Titova E, Tang J, and Zhang JH. (2008). Long-term effects of melatonin after intracerebral hemorrhage in rats. Acta Neurochir Suppl 105 99-100.

  1. 33. Hartman RE, Rojas H, Tang J, and Zhang J. (2008). Long-term behavioral characterization of a rat model of intracerebral hemorrhage. Acta Neurochir Suppl 105 125-6.

  1. 34. Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, Finn MB, and Holtzman DM. (2006). Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol Dis 24(3) 506-15.

  1. 35. Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, and Holtzman DM. (2005). Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J Neurosci 25(26) 6213-20.

  2. included in the Dana Foundation's annual report on breakthroughs in neuroscience

  3. commentary in the Journal of Neuroscience’s Journal Club

  1. 36. Hartman RE, Lee JM, Zipfel GJ, and Wozniak DF. (2005). Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in rats. Brain Res 1043(1-2) 48-56.

  1. 37. Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, and Holtzman DM. (2005). Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. J Biol Chem 280(52) 43236-42.

  1. 38. Izumi Y, Kitabayashi R, Funatsu M, Izumi M, Yuede C, Hartman RE, Wozniak DF, and Zorumski CF (2005). A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity. Neuroscience 136(1) 269-79.

  1. 39. Wozniak DF, Hartman RE, Boyle MP, Vogt SK, Brooks AR, Tenkova T, Young C, Olney JW, and Muglia LJ. (2004). Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis 17(3) 403-14.

  1. 40. Khuchua Z, Wozniak DF, Bardgett ME, Yue Z, McDonald M, Boero J, Hartman RE, Sims H, and Strauss AW (2003). Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory. Neuroscience 119(1) 101-11.

  1. 41. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW, and Wozniak DF. (2003) Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23(3) 876-82.

  1. 42. Hartman RE, Laurer H, Longhi L, Bales KR, Paul SM, McIntosh TK, and Holtzman DM. (2002). Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci 22(23) 10083-7.

  1. 43. Hartman RE, Wozniak DF, Nardi A, Olney JW, Sartorius L, and Holtzman DM. (2001). Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp Neurol 170(2) 326-44.

  1. 44. Schaefer ML, Wong ST, Wozniak DF, Muglia LM, Liauw JA, Zhuo M, Nardi A, Hartman RE, Vogt SK, Luedke CE, Storm DR, and Muglia LJ. (2001) Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice. J Neurosci 20(13) 4809-20.

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